Rail services in Harrogate and Knaresborough will be severely affected by a second day of strike action today.
Only about 10% of services are expected to operate on the line between York and Leeds.
A third strike is expected on Saturday.
People hoping to travel by train to the first day of the England vs New Zealand Test match at Headingley will be among those affected.
Harrogate station has been largely deserted for the last two days.
Many services ran yesterday but passengers had heeded warnings not to travel.
Rail campaigner Brian Dunsby, of the Harrogate Line Supporters Group, said:
“We are very concerned that this unnecessary national rail strike will risk driving people away from rail and thereby undermine and set back rail’s steady recovery from the pandemic.
“We express deep regret and concern given the uncertainty the industry and its consumers face following the effects of covid on passenger numbers.
“We ask management and government to get talking to the unions resolve things and for everyone to avoid further aggravating tensions by making hostile or critical comments. We urge the union to be more considerate of the impact on passengers of all categories.”
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A statement by Northern said:
“Customer safety is our priority, we advise you not to travel between Tuesday 21 and Sunday 26 June and make alternative plans.
“There will be no replacement buses or alternative travel provided.”