The A1 southbound between junction 47 and 48, near Boroughbridge, is closed following a serious accident.
North Yorkshire Police has said emergency services are at the scene of the incident that happened at 7.48am this morning.
The driver and passengers are believed to have serious, but not life threatening injuries. The accident involved a single vehicle.
The closure is in place on the southbound carriageway between junction 47, with exits to Knaresborough and the A59 and junction 48, for Boroughbridge.
Delays of over 30 minutes are being reported.
The police is asking for any witness to call 101 and press 1 and pass any information of the force control room.
They have also urged drivers to avoid the area.
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