Up to 30 festively-decorated tractors will depart from garden centre F Tate & Sons on Studley Road, near Ripon, at about 2.30pm.
The brightly lit vehicles will then follow a 21-mile route that passes through Bishop Monkton, Roecliffe, Boroughbridge and Skelton-on-Ure before finishing in Ripon Market Place at about 5.30pm.
Simon Dickinson, who organises the Nidderdale Charity Tractor Run each year, decided to stage the event to raise money for Harrogate-based Yorkshire Cancer Research.
Mr Dickinson, a window cleaner who grew up in Littlethorpe and now lives in Northallerton, said he wanted to raise money to help people affected by cancer and had been inspired by tinsel tractor runs held overseas.
He added he had been amazed by the response since the event was announced last night. Fifteen tractor drivers have already signed up.
Mr Dickinson, who is a member of West Yorkshire Vintage Tractor & Engine Club, added:
“I want to get it off the ground this year and then do it year after year.”
Tractor drivers pay £15 to enter and collections will be held at key points along the route.
The Nidderdale tractor run, which Mr Dickinson founded last year, attracted 55 vehicles and raised almost £2,000 this year. Next year’s event will be on June 30.
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